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- College of Medicine, Qatar university, Doha, Qatar [1]
- Department of Clinical Medicine, Weill Cornell Medicine, Qatar [1]
- Department of Medicine, Hamad Medical Corporation, Doha, Qatar [1]
- Department of Medicine, Hamad Medical Corporation, Doha, Qatar E-mail: [email protected] [1]
- Weill Cornell medicine, Doha, Qatar [1]
- Women's Wellness and Research Center, Hamad Medical Corporation, Doha, Qatar E-mail: [email protected] [1]
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What COVID-19 has taught the world
Background: A novel coronavirus (SARS-CoV-2) has captured global recognition in a short period of time by dramatically impacting people's everyday lives and emerged as a public health emergency. Undoubtedly it shows that lessons learned from past coronavirus epidemics such as the Middle East Respiratory Syndrome (MERS) and the Serious Acute Respiratory Syndrome (SARS) were not adequate and thus left us ill-prepared to deal with the challenges presently raised by the COVID-19 pandemic12. Methods: COVID-19 adds to the list of previous outbreaks of infectious disease epidemics that try to remind us that we live in an ecosystem where the relationship between human and animal life and the environment must be respected in order to survive and prosper. Rapid urbanization and our forestland invasion have created a new interface between humans and wildlife and have exposed humans to unfamiliar species frequently involving unfamiliar organisms and exotic wildlife23. Findings: Every pandemic is nature’s way of reminding us that the interrelationship between all forms of existence needs to be recognized. To limit new infectious outbreaks the transdisciplinary ‘One Health’ solution incorporating ‘Health in All Policy’ involving all stakeholders especially environmental health and social sciences is being advocated (Figure 1). Conclusion: Savings and investments should be made by everyone to meet the unexpected. Stigmatization and prejudice among individuals in the world should be discouraged. Special attention should be paid to the elderly as their immune system is weak. Health and safety precautions such as physical distancing and health hygiene etiquettes should be considered as part of life. Global experience teaches that containment steps and active tracing of contacts are effective to minimize the economic burden of disease and enhance knowledge of disease processes health issues disease emergence and re-emergence. These lessons will help us to battle future pandemics.
Ceftriaxone-induced hepatotoxicity in patients with common medical infections in Qatar: A retrospective study
Introduction: Ceftriaxone a third-generation cephalosporin is frequently used for the treatment of various bacterial infections as a broad-spectrum antibiotic for many decades. Although ceftriaxone is a well-tolerated drug in most cases it can lead to serious liver injury which can be a real challenge to the treating physician. Given the potentially serious adverse effects that can vary from mild biochemical abnormalities to complete liver failure we intend to assess the spectrum of liver injury based on biochemical criteria for patients treated with ceftriaxone for common bacterial infections in Qatar.Objectives: This study aimed to explore the incidence of ceftriaxone-induced liver injury at Hazm Mebaireek General Hospital Qatar and to evaluate the relationship of the ceftriaxone dose if any with liver dysfunction.Methods: This retrospective study included hospitalized adult patients treated with ceftriaxone at our hospital from January 2019 to December 2019 and analyzed demographic and clinical data obtained from electronic medical records. This study determined the incidence of liver injury (primary outcome) in patients treated with ceftriaxone (2 g/day) for ≥ 2 consecutive days by reviewing liver function test results until the day of discharge and at the first outpatient follow-up.
Results: The final data analysis included a total of 634 patients admitted and treated with ceftriaxone from January 2019 to December 2019.In the multivariate analysis with propensity score adjustment ceftriaxone was independently associated with liver injury especially when combined with other agents utilizing hepatic metabolism.Conclusions: Ceftriaxone was associated with a significantly higher incidence of liver injury (19.7%) when used along with other medications that are metabolized in the liver as found in the present study compared with other similar studies (approximately 2.9%–13.9%). Furthermore the incidence was too high to be ignored in clinical practice.